GRP78: Tables

Table 1: Human and mouse orthologs of Grp78/BiP (HspA5)

  Human Mouse
Entrez Gene 3309 14828
Ensembl ENSG00000044574 ENSMUSG00000026864
UniProt P11021 P20029
Reference sequence (mRNA) NM_005347.4 NM_001163434.1
Reference sequence (Protein) NP_005338.1 NP_001156906.1
Gene locus Chr9:125,234,853-125,241,330 Chr2:34,771,970-34,777,547
Pfam PF00012 PF00012

Table 2: The human HSPA family of molecular chaperones

Protein UniProt ID Aliases Length (aa) Chromosome Gene ID
HspA1A P0DMV8 Hsp70-1, Hsp72, HspA1, Hsp70-1a, Hsp70i 641 6p21.3 3303
HspA1B P0DMV9 Hsp70-2, Hsp70-1b 641 6p21.3 3304
HspA1L P34931 Hsp70-1L, Hsp70-hom, Hsp70-1t, Hum70t 641 6p21.3 3305
HspA2 P54652 Heat shock 70kD protein 2, Hsp70.2 639 14q24.1 3306
HspA5 P11021 Grp78, BiP, Hsp70-5, Mif-2 654 9q33.3 3309
HspA6 P17066 Hsp70-6, Hsp70B’ 643 1q23 3310
HspA7 P48741 Hsp70-7, Hsp70B 367 1q23.3 3311
HspA8 P11142 Hsp70-8, Hsc70, Hsc71, Hsp71, Hsp73 646 11q24.1 3312
HspA9 P38646 Hsp70-9, Grp75, HspA9B, MOT, MOT2, PBP74, mot-2, mtHsp70 679 5q31.1 3313
HspA12A O43301 Hsp70-12A, FLJ13874, KIAA0417 675 10q26.12 259217
HspA12B B7ZLP2 Hsp70-12B, RP23-32L15.1, 2700081N06Rik 685 20p13 116835
HspA13 P48723 Hsp70-13, Stch 471 21q11 6782
HspA14 Q0VDF9 Hsp70-14, Hsp70L1 509 10p13 51182

Table 3: Grp78/BiP (HspA5) of various eukaryotic organisms

Protein UniProt ID Aliases Gene Names Gene ID
Human
HspA5 P11021 Grp78, BiP, Hsp70-5, Mif-2 HSPA5, BIP, GRP78, MIF2, HEL-S-89n 3309
D. melanogaster
BiP P29844 78 kDa glucose-regulated protein homolog (Grp78-homolog),  binding-immunoglobulin protein homolog, heat shock 70 kDa protein cognate 3, heat shock protein cognate 72, heat shock 70 kDa protein cognate 3 (Hsc-3) HSC70-3, GRP78, HSC3, BIP, CG4147, dmHsc72, dBIP 32133
S. cerevisiae
Grp78/BiP P16474 78 kDa glucose-regulated protein homolog (Grp78-homolog),  binding-immunoglobulin protein homolog KAR2, GRP78 853418
F. chinensis
Grp78/BiP B8LF10 Glucose-regulated protein 78 N/A ?
O. sativa
BiP1 Q6Z7B0 Heat shock 70 kDa protein BIP1, luminal-binding protein 1 (OsBiP1) BIP1 4328075

Os02g0115900

BiP2 Q53RJ5 Heat shock 70 kDa protein BIP2, luminal-binding protein 2 (OsBiP2) BIP2 4338568

Os03t0710500-00

BiP3 Q6L590 Heat shock 70 kDa protein BIP33, luminal-binding protein 4 (OsBiP3) BIP3 4328075

Os05g0367800

BiP4 Q75HQ0 Heat shock 70 kDa protein BIP4, luminal-binding protein 4 (OsBiP4) BIP4 Os06t0483100-00
BiP5 Q6Z058 Heat shock 70 kDa protein BIP5, luminal-binding protein 5 (OsBiP5); Grp78-5 BIP5 Os08t0197700-00

Table 4: Inhibitors of Grp78/BiP (HspA5)

Agent References
Antibodies
C-20 (polyclonal) Davidson et al. (2005) 8
C-38 (monoclonal) de Ridder et al. (2012) 316
C-107 (monoclonal) de Ridder et al. (2012) 316
N-20 (polyclonal) Davidson et al. (2005) 8
anti-CTD (polyclonal) Misra et al. (2009) 314, Misra et al. (2010) 301, 315
SAM-6 (monoclonal) Brändlein et al. (2007) 320
Natural Compounds
EGCG Ermakova et al. (2006) 323
Honokiol Martin et al. (2013) 324
AB5 subtilase cytotoxin (SubAB) Paton et al. (2006) 251
Verrucosidin Park et al. (2007) 331
Versipelostatin Matsuo et al. (2009) 328
Prunustatin A Umeda et al. (2005) 329
Peptides
Bag-1 peptide Maddalo et al. (2012) 333
GMBP1 (ETAPLSTMLSPY) Kang et al. (2013) 336
M4 Cunningham et al. (2005) 335, Gupta et al. (2006) 334
Pep42 (CTVALPGGYVRVC) Yoneda et al. (2008) 337
WIFPWIQL Arap et al. (2004) 122
WDLAWMFRLPVG Arap et al. (2004) 122
GIRLRG Passarella et al. (2010) 339
Fusion Proteins
EGF-SubA Backer et al. (2009) 340
Rhutenium Complexes
IT-139/KP-1339 Dickson et al. (2011) 341
Thiazole Benzenesulfonamides
HA15 Cerezo et al. (2016) 344
Acetohydrazide Derivatives
VH1019 Viswanath et al. (2018) 347